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Meredith S. Gregory, Ph.D.
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It has been proposed that the constitutive
expression of Fas Ligand (FasL) in the eye maintains immune
privilege, in part, through the induction of apoptosis in
infiltrating Fas+ T cells. However, the role of FasL in immune
privilege remains controversial due to studies that indicate
FasL can be both pro- and anti- inflammatory.My current research
is directed at elucidating the mechanisms by which Fas Ligand
contributes to establishing and maintaining immune privilege
within the eye, and determining how the different forms of
FasL may be used to (i) promote rejection of ocular tumors,
(ii) prevent the inflammation-mediated destruction of ocular
tissue, and (iii) improve cornea graft survival.
Publications
Gregory, M.S., A.C. Repp, A.M. Hohlbaum,
R.R. Saff, A Marshak-Rothstein, and B.R. Ksander. Membrane
Fas Ligand Activates Innate Immunity and Terminates Ocular
Immune Privilege. J. Immunol. 2002. In Press.
Kovacs, E.J. K.A.N. Messingham, and M.S.
Gregory. Estrogen regulation of immune responses after injury.Molec.
Cell. Endocrinol. 2002. in press.
Kovacs, E.J., L.A. Duffner, T.P. Plackett,
M.S. Gregory, and K.A.Grabowski. Survival and cell mediated
immunity after burn injury in aged mice. J. Amer. Aging
Assoc. 2002. In press.
Hohlbaum, A.M., M.S. Gregory, S-T. Ju,
and A. Marshak-Rothstein. Fas-Ligand engagement of resident
peritoneal macrophages in vivo induces apoptosis and the production
of neutrophil chemotactic factors. J. Immunol. 2001.
167: 6217-6224.
Gregory, M.S., L.A. Duffner, E.L. Hahn,
H.-H. Tai, D.E. Faunce, and E.J. Kovacs. Differential production
of prostaglandin E 2 in male and female mice subjected to
thermal injury contributes to the gender difference in immune
function: Possible role for 15-hydroxyprostaglandin dehydrogenase.
Cell. Immunol. 2000. 205:94-102.
Fontanilla C, Faunce DE, Gregory MS, Colantoni
A, Messingham KAN, Duffner LA, and EJ Kovacs.Anti-interleukin-6
antibody treatment restores cell mediated immune function
in mice with acute alcohol exposure prior to burn trauma.
Alcohol: Clin. Expt. Res. 2000. 24:1392-1399.
Durbin EA, Duffner LA, Messingham KAN,
Fontanilla CV, Gregory MS, and EJ Kovacs.The role of interleukin-6
in interferon-a production in thermally injured mice. Cytokine.
2000. 12: 1669-1675.
GregoryMS, Faunce DE, and EJ Kovacs. A
temporal difference in the cell mediated immune response in
male and female mice following thermal injury: possible role
of IL-6. J. Leukocyte Biol. 2000; 67:319-326.
GregoryMS, Faunce DE, Duffner LA, and EJ
Kovacs. Estrogen mediates the gender difference in post-burn
immunosuppression. J. Endocrinol. 2000; 164;129-138.
Faunce DE, Llanas JN,Patel PJ, Gregory
MS, Duffner LA, DriesDJ, and EJ Kovacs. Neutrophil chemokine
production in the skin following scald injury. Burns.
1999;25:403-410.
PatelPJ, Faunce DE, GregoryMS, Duffner,
LA,and EJ Kovacs.Elevated pulmonary neutrophils and prolonged
production of pulmonary MIP-2 following burn injury with prior
alcohol exposure. Amer. J. Respir. Cell. Molec. Biol.
1999;20:1229-1237.
Faunce DE, Gregory MS, and EJ Kovacs. Glucocorticoids
protect against suppression of T cell responses in a murine
model of acute ethanol exposure and thermal injury by regulating
IL-6. J. Leukocyte Biol. 1998; 54:724-732.
Faunce DE, Gregory MS, and EJ Kovacs.Acute
alcohol exposure prior to thermal injury results in decreased
T-cell responses mediated in part by increased production
of IL-6. Shock 1998; 10:135-140.
FaunceDE, GregoryMS, and EJ Kovacs. The
effects of acute ethanol exposure on cellular immune responses
in a murine model of thermal injury. J. Leukocyte Biol.
1997; 62:733-740.
Kovacs EJ, Gregory MS, and FJ Mott. Estrogen
control of macrophage cytokine gene expression: An explanation
for gender differences in the immune response.In: Faist, E,
Editor.The Immune Consequences of Trauma, Shock and Sepsis.
Bologna, Italy:Monduzzi Editoire; 1997. P.327-331.
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