Charles Y. Kim MD Schepens Eye Research Institute 20 Staniford St Boston, MA 02114 Tel.: (617) 912-7436 E-Mail: cykim@vision.eri.harvard.edu Sponsor: Wayne Streilein, M.D. waynes@vision.eri.harvard.edu

"The Molecular Bases of Eye Diseases training program at Harvard Medical School provides access to incredible facilities and faculty that rival any in the world."

MHC Class Ib molecules and ocular immune privilege

MHC class Ib molecules are a subset of the MHC Class I molecules that display several unique properties that distinguish them from the "classical" MHC Class I molecules. Multiple studies have shown them to have inhibitory effects on NK cells, T cells, and macrophages. A few studies have shown that some of these MHC Class I molecules are indeed expressed in the eye, despite their globally limited distribution. The aim of this project is to determine the expression of cell-associated and soluble class Ib molecules on cells and tissues of ocular anterior segment and aqueous humor, and then examine their effects on immune effector cells.

Education/Training

1993-97 B.S.E. University of Pennsylvania (Computer Science Engineering)
1997-01 M.D. Columbia University
2001-02 Surgery residency Yale - New Haven Hospital

Publications

Kim CY, Kumar A, Sampath L, Sokol K, Modak S. Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats. American Journal of Kidney Diseases 2002 ; 39(1):165-73.

Choi L, Kim CY, Choudrhri AF, Oz MC, Modak S. Control of Percutaneous Driveline Infections Through Biomaterial Selection and Antimicrobial Coating [abstract]. ASAIO 1999; 45(2):157.

Cereb N, Kim C, Hughes AL, Yang SY. Molecular analysis of HLA-B35 alleles and their relationship to HLA-B15 alleles. Tissue Antigens 1997; 49(4):389-96.

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Last updated: October 28, 2002